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High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Dominic Hoepfner1*+, Stephen B. Helliwell1+, Heather Sadlish1+, Sven Schuierer1, Ireos Filipuzzi1, Sophie Brachat1, Bhupinder Bhullar1, Uwe Plikat1, Yann Abraham1, Marc Altorfer1, Thomas Aust1, Lukas Baeriswyl1, Raffaele Cerino1, Lena Chang1, David Estoppey1, Juerg Eichenberger1, Mathias Frederiksen1, Nicole Hartmann1, Annika Hohendahl1, Britta Knapp1, Philipp Krastel1, Nicolas Melin1, Florian Nigsch1, Edward J. Oakeley1, Virginie Petitjean1, Frank Petersen1, Ralph Riedl1, Esther K. Schmitt1, Frank Staedtler1, Christian Studer1, John A. Tallarico1, Stefan Wetzel1, Mark C. Fishman2, Jeffery A. Porter2, N. Rao Movva1

Affiliations:

Published in Microbiological Research 169 (2014) pp. 107-120

A detailed description of the applied methodologies and tested compounds can be found at the link above. At the linked site you can also download the supplemental material for further analysis. Alternatively, The underlying data tables and supplemental materials mentioned in the publication can be downloaded from http://doi.org/10.5061/dryad.v5m8v

To query the data enter a compound number or systematic gene name into the corresponding box and hit enter

Single compound HIP HOP results

sensitivity vs. z-score

enter CMB ID or name of compound

Single compound HIP HOP results

chromosome location vs. sensitivity

enter CMB ID or name of compound

Single strain HIP HOP profile

compound vs. z-score

enter systematic or common name of gene

Strain correlation across HIP assays

shows correlation of heterozygous deletion strains to each other across all performed HIP experiments

enter systematic or common name of gene

Strain correlation across HOP assays

shows correlation of homozygous deletion strains to each other across all performed HOP experiments

enter systematic or common name of gene

Compound correlation across HIP assays

shows correlation of compounds to each other across all performed HIP experiments

enter CMB ID or name of compound

Compound correlation across HOP assays

shows correlation of compounds to each other across all performed HOP experiments

enter CMB ID or name of compound

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